A Spanish scientist has opened the way to a new understanding of what
causes metastasis in cancer cells. The study which took place at IRB Barcelona
has identified the cells responsible for initiating and promoting metastasis in
a bunch of different types of human tumors.
But what is metastasis? Cancer metastasis
is the spread of cancer cells to tissues and organs beyond where the tumor
originated and the formation of new tumors, and is the single event that
results in the death of most patients with cancer (2).
Fat intake and
CD36
In the study, mice given a high-fat diet (specifically,
palmitic acid) developed the most aggressive metastases. This allowed
researchers to conclude that fat intake could enhance the metastasis process.
In the absence of the CD36 protein, the human tumors analyzed did not develop
metastasis. Further, the inhibition of this protein also dramatically reduced
the size of existing metastases. (1).
The researchers discovered the
metastatic CD36 cells in samples of patients with oral cancer with different
degrees of aggressiveness. Of the tumors analyzed, very few were found to have
the capacity for metastasis, but with the addition of CD36 it made tumors
metastatic. Further, the effect witnessed by the team of CD36 in cancer cells
is similar in melanoma cells, luminal breast cancer cells, ovarian, bladder and
lung cancer.
Researchers agree that even though tests have not been
done in all forms of cancer, they can state that CD36 is a general marker for
metastasis of cells. This will allow further research to be done on the CD36
protein and to determine the distribution of metastasis in the cancer cells,
and to determine where they anchor to when they leave it, or why they are so
sensitive to fat (1).
When mice were provided with a
high-fat diet (fifteen percent higher than normal, mimicking a so-called
cafeteria diet) and inoculated with a type of oral cancer. Usually, the
inoculation would amount to 30% of animals developing metastasis, but with a much
higher amount of fat in the blood, around 80% of the mice developed numerous
and large metastases (1).
Study conclusions
The protein CD36, which absorbs fat from the cell
membrane, is an essential factor that determines whether tumor cells become metastatic (1). Further, they found that there
appears to be a direct link between fat intake and an increase in metastatic
potential through CD36 (1). The IRB Barcelona team is looking to
develop antibodies against CD36 with the potential to treat metastasis in
cancer patients.
The researchers have opened new doorways when it comes to cancer
treatment, a treatment that will dramatically decrease the chances of
metastasis in cancer patients. Even though the research was only done on mice,
the possibilities for the future are endless. In some time we could end up
having therapies that prevent metastases from developing and will help save
lives.
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These enzymes are essential to the body because good health is heavily dependent on good digestion, and good digestion is totally dependent upon having sufficient enzymes in the body. Vitamins, minerals, and hormones must have enzymes to work properly. These enzymes are also needed for breaking down the fats in the body.
8. 10 Essential Fatty Acids
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10. 18 Amino Acids
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This formula helps in the disintegration of vitamin C in the body. The Bioflavonoids come from all natural sources particularly Lemon, Orange, Grapefruit, Lime and Tangerine.
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C24/7 Technology
PHYTO-ALKATECH: A powerful complex of natural alkaline ingredients designed to enhance the alkalinity of this formulation and also to protect and neutralize possible acid damage when it reaches the stomach. It preserves the purity and potency of this natura-ceuticals.
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